Download Biological Research on Addiction. Comprehensive Addictive by Peter M. Miller PDF

By Peter M. Miller

Biological learn on Addiction examines the neurobiological mechanisms of drug use and drug habit, describing how the mind responds to addictive elements in addition to the way it is plagued by medicinal drugs of abuse. The book's 4 major sections learn behavioral and molecular biology; neuroscience; genetics; and neuroimaging and neuropharmacology as they relate to the addictive process.

This quantity is principally potent in proposing present wisdom at the key neurobiological and genetic parts in an individual’s susceptibility to drug dependence, in addition to the approaches through which a few participants continue from informal drug use to drug dependence.

Biological study on Addiction is certainly one of 3 volumes comprising the 2,500-page sequence, Comprehensive Addictive Behaviors and Disorders. This sequence offers the main whole choice of present wisdom on addictive behaviors and issues so far. in brief, it's the definitive reference paintings on addictions.

  • Each article presents thesaurus, complete references, prompt readings, and an inventory of net resources
  • Edited and authored by means of the leaders within the box worldwide – the broadest, so much professional insurance available
  • Discusses the genetic foundation of addiction
  • Covers uncomplicated technological know-how study from quite a few animal studies

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Extra info for Biological Research on Addiction. Comprehensive Addictive Behaviors and Disorders, Volume 2

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This traditional animal model of alcohol abuse is framed by the behaviorist view that emphasizes the action of alcohol as a positive reinforcer, much like food, water, salt, and other “natural” reinforcers. 1 ml of a 10% ethanol solution). Thus, alcohol is a reinforcer for rats. Usually rats are trained to self-administer alcohol by pressing a lever or nose-poking into a hole during 30-min sessions. They also usually have choice between two levers (or two 27 holes), one active lever delivering alcohol solution (usually 10% v vÀ1) and one inactive lever (no responses) to control for motor impairment.

Although the NHP does need to be trained to lever press to produce an IV or IG infusion of alcohol, induction procedures such as those described earlier are not necessary. An advantage of using the IV and IG routes is that the doses of alcohol that could be selfinjected could be systematically varied. g. 6–8 g kgÀ1 dayÀ1) are followed by periods of voluntary abstinence and withdrawal signs including tremors, vomiting, and convulsions. Such cyclic patterning of intake and abstinence across days is also observed in alcoholic persons.

Age-related differences in the blood alcohol levels of Wistar rats. Pharmacology Biochemistry and Behavior 91 (4), 560–565. , 1995. From controlled drug intake to loss of control: the irreversible development of drug addiction in the rat. Behavioral Brain Research 70 (1), 77–94. gov – National Institute of Drug Abuse (NIDA). I. BEHAVIORAL BIOLOGY, PRECLINICAL ANIMAL STUDIES OF ADDICTION C H A P T E R 4 Nonhuman Primate Models of Alcohol Abuse and Alcoholism Elise M. Weerts and Barbara J. Kaminski Johns Hopkins University School of Medicine, Baltimore, MD, USA O U T L I N E Introduction 31 Use of Nonhuman Primates in Alcohol Research 32 Pharmacological Models Models of Alcohol Response Models of Physical Dependence Models of Alcohol-Related Liver Damage Summary of Pharmacological Models 32 33 33 33 33 Behavioral Models Induction of Alcohol Drinking 34 34 Alcohol Preference Alcohol Self-Administration Alcohol Self-Dosing Alcohol Seeking and Relapse Neuropharmacology and Medications Development Use of Behavioral Models to Examine Risk Factors Summary of Behavioral Models Conclusions INTRODUCTION 40 Alcohol use and drinking patterns can be characterized when “standard drink units,” which are based on the total grams of “pure” ethyl alcohol (ethanol) are used.

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